Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes.

Bally, Lia; Kempf, Patrick; Züger, Thomas; Speck, Christian; Pasi, Nicola; Ciller, Carlos; Feller, Katrin Madeleine; Loher, Hannah; Rosset, Robin; Wilhelm, Matthias; Boesch, Christoph Hans; Buehler, Tania; Dokumaci, Ayse Sila; Tappy, Luc; Stettler, Christoph (2017). Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes. Nutrients, 9(2) Molecular Diversity Preservation International MDPI 10.3390/nu9020164

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This paper aims to compare the metabolic effects of glucose-fructose co-ingestion (GLUFRU) with glucose alone (GLU) in exercising individuals with type 1 diabetes mellitus. Fifteen male individuals with type 1 diabetes (HbA1c 7.0% ± 0.6% (53 ± 7 mmol/mol)) underwent a 90 min iso-energetic continuous cycling session at 50% VO2max while ingesting combined glucose-fructose (GLUFRU) or glucose alone (GLU) to maintain stable glycaemia without insulin adjustment. GLUFRU and GLU were labelled with (13)C-fructose and (13)C-glucose, respectively. Metabolic assessments included measurements of hormones and metabolites, substrate oxidation, and stable isotopes. Exogenous carbohydrate requirements to maintain stable glycaemia were comparable between GLUFRU and GLU (p = 0.46). Fat oxidation was significantly higher (5.2 ± 0.2 vs. 2.6 ± 1.2 mg·kg(-1)·min(-1), p < 0.001) and carbohydrate oxidation lower (18.1 ± 0.8 vs. 24.5 ± 0.8 mg·kg(-1)·min(-1)p < 0.001) in GLUFRU compared to GLU, with decreased muscle glycogen oxidation in GLUFRU (10.2 ± 0.9 vs. 17.5 ± 1.0 mg·kg(-1)·min(-1), p < 0.001). Lactate levels were higher (2.2 ± 0.2 vs. 1.8 ± 0.1 mmol/L, p = 0.012) in GLUFRU, with comparable counter-regulatory hormones between GLUFRU and GLU (p > 0.05 for all). Glucose and insulin levels, and total glucose appearance and disappearance were comparable between interventions. Glucose-fructose co-ingestion may have a beneficial impact on fuel metabolism in exercising individuals with type 1 diabetes without insulin adjustment, by increasing fat oxidation whilst sparing glycogen.

Item Type:

Journal Article (Original Article)

Division/Institute:

?? DCD5A442BA03E17DE0405C82790C4DE2 ??
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
?? DCD5A442C386E17DE0405C82790C4DE2 ??
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Endokrinologie / Diabetologie (Erwachsene)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy > ARTORG Center - Ophthalmic Technology Lab
?? 32670DC8468E049AE053980C5C823463 ??
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Bally, Lia; Kempf, Patrick; Züger, Thomas; Ciller, Carlos; Feller, Katrin Madeleine; Loher, Hannah; Wilhelm, Matthias; Boesch, Christoph Hans; Buehler, Tania; Dokumaci, Ayse Sila and Stettler, Christoph

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

2072-6643

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Lia Bally

Date Deposited:

27 Jul 2017 14:46

Last Modified:

05 Jun 2018 13:32

Publisher DOI:

10.3390/nu9020164

PubMed ID:

28230765

Uncontrolled Keywords:

carbohydrates; exercise; fructose; glucose; glycaemia; substrate oxidation; type 1 diabetes

BORIS DOI:

10.7892/boris.96300

URI:

https://boris.unibe.ch/id/eprint/96300

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