Reflection-artifact-free photoacoustic imaging using PAFUSion (photoacoustic-guided focused ultrasound)

Kuniyil Ajith Singh, Mithun; Jaeger, Michael; Frenz, Martin; Steenbergen, Wiendelt (2016). Reflection-artifact-free photoacoustic imaging using PAFUSion (photoacoustic-guided focused ultrasound). In: Oraevsky, Alexander A.; Wang, Lihong V. (eds.) Photons Plus Ultrasound: Imaging and Sensing 2016. Proceedings of SPIE: Vol. 9708 (97081R). SPIE 10.1117/12.2212775

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Reflection artifacts caused by acoustic inhomogeneities are a main challenge to deep-tissue photoacoustic imaging. Photoacoustic transients generated by the skin surface and superficial vasculature will propagate into the tissue and reflect back from echogenic structures to generate reflection artifacts. These artifacts can cause problems in image interpretation and limit imaging depth. In its basic version, PAFUSion mimics the inward travelling wave-field from blood vessel-like PA sources by applying focused ultrasound pulses, and thus provides a way to identify reflection artifacts. In this work, we demonstrate reflection artifact correction in addition to identification, towards obtaining an artifact-free photoacoustic image. In view of clinical applications, we implemented an improved version of PAFUSion in which photoacoustic data is backpropagated to imitate the inward travelling wave-field and thus the reflection artifacts of a more arbitrary distribution of PA sources that also includes the skin melanin layer. The backpropagation is performed in a synthetic way based on the pulse-echo acquisitions after transmission on each single element of the transducer array. We present a phantom experiment and initial in vivo measurements on human volunteers where we demonstrate significant reflection artifact reduction using our technique. The results provide a direct confirmation that reflection artifacts are prominent in clinical epi-photoacoustic imaging, and that PAFUSion can reduce these artifacts significantly to improve the deep-tissue photoacoustic imaging.

Item Type:

Book Section (Book Chapter)


08 Faculty of Science > Institute of Applied Physics
08 Faculty of Science > Institute of Applied Physics > Biomedical Photonics

UniBE Contributor:

Jaeger, Michael and Frenz, Martin


600 Technology > 620 Engineering
500 Science > 530 Physics


Proceedings of SPIE






Simone Corry

Date Deposited:

12 Jul 2017 15:03

Last Modified:

11 Sep 2017 19:31

Publisher DOI:





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