Spectral correction of OA signals based on multiple irradiation sensing: experimental validation

Held, Kai Gerrit; Jaeger, Michael; Frenz, Martin; Akarçay, Hidayet Günhan (2016). Spectral correction of OA signals based on multiple irradiation sensing: experimental validation. In: Oraevsky, Alexander A.; Wang, Lihong V. (eds.) Photons Plus Ultrasound: Imaging and Sensing 2016. Proceedings of SPIE: Vol. 9708 (97081E). SPIE 10.1117/12.2214299

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In this study we show that the spectral distortion of OA signals, caused by wavelength-dependent optical attenuation inside the bulk tissue, can be corrected based on OA imaging, when using multiple-irradiation sensing. The tissue is modeled as a strongly scattering background, in which a discrete number of blood vessels, characterized by a higher absorption than the background, are sparsely distributed. OA signals generated by these vessels, which serve as intrinsic “fluence detectors”, are recorded as a function of irradiation position. In order to account for realistic situations, we have developed a semi-empirical light diffusion model that is fitted to the recorded signals, so as to determine the background’s optical effective attenuation coefficient for arbitrarily shaped tissues. The experimental validation of this model was performed on tissue-mimicking phantoms. The results demonstrate a successful correction of the measured OA spectrum of the embedded vessel-like inclusions, in the presence of lateral geometrical boundaries and when vessel-like absorbing structures influence the light propagation.

Item Type:

Book Section (Book Chapter)

Division/Institute:

08 Faculty of Science > Institute of Applied Physics
08 Faculty of Science > Institute of Applied Physics > Biomedical Photonics

UniBE Contributor:

Held, Kai Gerrit; Jaeger, Michael; Frenz, Martin and Akarçay, Hidayet Günhan

Subjects:

600 Technology > 620 Engineering
500 Science
500 Science > 530 Physics

Series:

Proceedings of SPIE

Publisher:

SPIE

Language:

English

Submitter:

Simone Corry

Date Deposited:

13 Jul 2017 07:45

Last Modified:

11 Sep 2017 19:26

Publisher DOI:

10.1117/12.2214299

BORIS DOI:

10.7892/boris.96981

URI:

https://boris.unibe.ch/id/eprint/96981

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