The effects of mechanical ventilation on hepato-splanchnic perfusion

Jakob, Stephan (2010). The effects of mechanical ventilation on hepato-splanchnic perfusion. Current opinion in critical care, 16(2), pp. 165-168. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/MCC.0b013e3283374b1c

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PURPOSE OF REVIEW: Mechanical ventilation is a cornerstone of ICU treatment. Because of its interaction with blood flow and intra-abdominal pressure, mechanical ventilation has the potential to alter hepato-splanchnic perfusion, abdominal organ function and thereby outcome of the most critically ill patients. RECENT FINDINGS: Mechanical ventilation can alter hepato-splanchnic perfusion, but the effects are minimal (with moderate inspiratory pressures, tidal volumes, and positive end-expiratory pressure levels) or variable (with high ones). Routine nursing procedures may cause repeated episodes of inadequate hepato-splanchnic perfusion in critically ill patients, but an association between perfusion and multiple organ dysfunction cannot yet be determined. Clinical research continues to be challenging as a result of difficulties in measuring hepato-splanchnic blood flow at the bedside. SUMMARY: Mechanical ventilation and attempts to improve oxygenation such as intratracheal suctioning and recruitment maneuvers, may have harmful consequences in patients with already limited cardiovascular reserves or deteriorated intestinal perfusion. Due to difficulties in assessing hepato-splanchnic perfusion, such effects are often not detected.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Jakob, Stephan


600 Technology > 610 Medicine & health




Lippincott Williams & Wilkins




Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

08 Jun 2016 10:20

Publisher DOI:


PubMed ID:


Web of Science ID:


URI: (FactScience: 201591)

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