The neuronal correlates of mirror illusion in children with spastic hemiparesis: a study with functional magnetic resonance imaging.

Weisstanner, Christian; Saxer, Stefanie; Wiest, Roland; Kaelin, Alain; Newman, Christopher J; Steinlin, Maja; Grunt, Sebastian (2017). The neuronal correlates of mirror illusion in children with spastic hemiparesis: a study with functional magnetic resonance imaging. Swiss medical weekly, 147, w14415. EMH Schweizerischer Ärzteverlag 10.4414/smw.2017.14415

[img]
Preview
Text
14415.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (334kB) | Preview

AIM To investigate the neuronal activation pattern underlying the effects of mirror illusion in children/adolescents with normal motor development and in children/adolescents with hemiparesis and preserved contralateral corticospinal organisation. METHOD The type of cortical reorganisation was classified according to results of transcranial magnetic stimulation. Only subjects with congenital lesions and physiological contralateral cortical reorganisation were included. Functional magnetic resonance imaging was performed to investigate neuronal activation patterns with and without a mirror box. Each test consisted of a unimanual and a bimanual motor task. RESULTS Seven children/adolescents with congenital hemiparesis (10-20 years old, three boys and four girls) and seven healthy subjects (8-17 years old, four boys and three girls) participated in this study. In the bimanual experiment, children with hemiparesis showed a significant effect of the mirror illusion (p<0.001 at voxel level, family-wise error corrected at cluster level) in the dorsolateral prefrontal cortex and anterior cingulate cortex of the affected and unaffected hemispheres, respectively. No significant effects of the mirror illusion were observed in unimanual experiments and in healthy participants. INTERPRETATION Mirror illusion in children/adolescents with hemiparesis leads to activation of brain areas involved in visual conflict detection and cognitive control to resolve this conflict. This effect is observed only in bimanual training. We consider that for mirror therapy in children and adolescents with hemiparesis a bimanual approach is more suitable than a unimanual approach.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Weisstanner, Christian; Wiest, Roland; Kaelin, Alain; Steinlin, Maja and Grunt, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

28 Jul 2017 10:58

Last Modified:

30 Jul 2017 02:14

Publisher DOI:

10.4414/smw.2017.14415

PubMed ID:

28322427

BORIS DOI:

10.7892/boris.99010

URI:

https://boris.unibe.ch/id/eprint/99010

Actions (login required)

Edit item Edit item
Provide Feedback