Ebneter, Andreas; Kokona, Despina; Jovanovic, Joël; Zinkernagel, Martin (2017). Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy. Translational vision science & technology, 6(2), p. 10. Association for Research in Vision and Ophthalmology 10.1167/tvst.6.2.10
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This report provides sound evidence that the small molecule pharmaceutical PLX5622, a highly selective CSF-1R kinase inhibitor, crosses the blood-retina barrier and suppresses microglia activity. Members of this class of drug are in advanced clinical development stages and may represent a novel approach to modulate ocular inflammatory processes.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Ebneter, Andreas, Zinkernagel, Martin Sebastian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2164-2591 |
Publisher: |
Association for Research in Vision and Ophthalmology |
Language: |
English |
Submitter: |
Andreas Ebneter |
Date Deposited: |
17 Aug 2017 12:47 |
Last Modified: |
02 Mar 2023 23:29 |
Publisher DOI: |
10.1167/tvst.6.2.10 |
PubMed ID: |
28458957 |
BORIS DOI: |
10.7892/boris.99595 |
URI: |
https://boris.unibe.ch/id/eprint/99595 |
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