Andresen-Streichert, Hilke; Beres, Yannick; Weinmann, Wolfgang; Schröck, Alexandra; Müller, Alexander; Skopp, Gisela; Pischke, Sven; Vettorazzi, Eik; Lohse, Ansgar; Nashan, Björn; Sterneck, Martina (2017). Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study. Transplant international, 30(6), pp. 611-620. Wiley-Blackwell 10.1111/tri.12949
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Phosphatidylethanol (PEth) is a new, highly specific alcohol marker. The aim of this study was to assess its diagnostic value in the liver transplant setting. In 51 pre- and 61 post-transplant patients with underlying alcoholic liver disease PEth, ethanol, methanol, carbohydrate-deficient transferrin (CDT), and ethyl glucuronide in urine (uEtG) and hair (hEtG) were tested and compared with patients' questionnaire reports. Twenty-eight (25%) patients tested positive for at least one alcohol marker. PEth alone revealed alcohol consumption in 18% of patients. With respect to detection of alcohol intake in the preceding week, PEth showed a 100% sensitivity. PEth testing was more sensitive than the determination of ethanol, methanol, CDT or uEtG alone [sensitivity 25% (confidence interval (CI) 95%, 7-52%), 25% (7-52%), 21% (6-45%) and 71% (41-91%), respectively], or ethanol, methanol and uEtG taken in combination with 73% (45-92%). Specificity of all markers was 92% or higher. Additional testing of hEtG revealed alcohol consumption in seven patients, not being positive for any other marker. Phosphatidylethanol was a highly specific and sensitive marker for detection of recent alcohol consumption in pre- and post-transplant patients. The additional determination of hEtG was useful in disclosing alcohol consumption 3-6 months retrospectively.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Chemistry and Toxicology |
UniBE Contributor: |
Weinmann, Wolfgang |
ISSN: |
0934-0874 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Antoinette Angehrn |
Date Deposited: |
07 Aug 2017 13:05 |
Last Modified: |
05 Dec 2022 15:05 |
Publisher DOI: |
10.1111/tri.12949 |
PubMed ID: |
28295675 |
Uncontrolled Keywords: |
alcoholic liver disease; carbohydrate-deficient transferrin; cirrhosis; ethyl glucuronide; methanol; phosphatidylethanol |
BORIS DOI: |
10.7892/boris.100161 |
URI: |
https://boris.unibe.ch/id/eprint/100161 |
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