Synapses form in skeletal muscles lacking neuregulin receptors.

Escher, Pascal; Lacazette, E; Courtet, M; Blindenbacher, A; Landmann, L; Bezakova, G; Lloyd, K C; Mueller, U; Brenner, H R (2005). Synapses form in skeletal muscles lacking neuregulin receptors. Science, 308(5730), pp. 1920-1923. American Association for the Advancement of Science 10.1126/science.1108258

Text 1920.full.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (451kB) | Request a copy

The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.

Interest & Impact

Downloads

1 since deposited on 10 Jul 2017
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item