CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms

Oppliger Leibundgut, Elisabeth; Rogenmoser-Dissler, Daniela; de Beer, Dirk; Porret, Naomi A; Zibellini, Silvia; Dürig, Jan; Röth, Alexander; Klingbiel, Dirk; Baerlocher, Gabriela M (2012). CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms. Leukemia research, 36(9), pp. 1204-7. Amsterdam: Elsevier 10.1016/j.leukres.2012.05.015

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The distinction of CLL from other mature B-cell neoplasms, especially from leukemic forms of mantle cell lymphoma or splenic marginal zone lymphoma, can be difficult but has important prognostic and therapeutic implications. We measured CLLU1 (CLL upregulated gene1) mRNA by qPCR and found a highly significant difference between CLL and other lymphoid neoplasms (AUC 0.96, 95%CI 0.93-0.99). Based on our cut-off values we can predict CLL and other mature B-cell neoplasms with high probability (PPV 99% and 94%). Analysis of CLLU1 expression is a rapid and reliable tool that may facilitate the diagnosis of mature B-cell neoplasms especially in inconclusive cases.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
UniBE Contributor:	Oppliger Leibundgut, Elisabeth, Baerlocher, Gabriela M.
ISSN:	0145-2126
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:28
Last Modified:	05 Dec 2022 14:08
Publisher DOI:	10.1016/j.leukres.2012.05.015
PubMed ID:	22738889
Web of Science ID:	000306523600030
URI:	https://boris.unibe.ch/id/eprint/10369 (FactScience: 216241)