Munk, Marion R; Zimmermann, Helena; Berger, Lieselotte Erika; Huf, Wolfgang; Ebneter, Andreas; Wolf, Sebastian; Zinkernagel, Martin (2017). OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices. PLoS ONE, 12(5), e0177059. Public Library of Science 10.1371/journal.pone.0177059
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PURPOSE
To compare the quality of four OCT-angiography(OCT-A) modules.
METHOD
The retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). The device-software generated en-face OCT-A images of the superficial (SCP) and deep capillary plexuses (DCP) were evaluated and scored by 3 independent retinal imaging experts. The SCP vessel density was assessed using Angiotool-software. After the inter-grader reliability assessment, a consensus grading was performed and the modules were ranked based on their scoring.
RESULTS
There was no significant difference in the vessel density among the modules (Zeiss 48.7±4%, Optovue 47.9±3%, Topcon 48.3±2%, Heidelberg 46.5±4%, p = 0.2). The numbers of discernible vessel-bifurcations differed significantly on each module (Zeiss 2±0.9 bifurcations, Optovue 2.5±1.2, Topcon 1.3±0.7 and Heidelberg 0.5±0.6, p≤0.001). The ranking of each module differed depending on the evaluated parameter. In the overall ranking, the Zeiss module was superior and in 90% better than the median (Bonferroni corrected p-value = 0.04). Optovue was better than the median in 60%, Topcon in 40% and Heidelberg module in 10%, however these differences were not statistically significant.
CONCLUSION
Each of the four evaluated OCT-A modules had particular strengths, which differentiated it from their competitors.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Zimmermann, Helena, Berger, Lieselotte Erika, Ebneter, Andreas, Wolf, Sebastian (B), Zinkernagel, Martin Sebastian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Sebastian Wolf |
Date Deposited: |
09 Nov 2017 13:41 |
Last Modified: |
02 Mar 2023 23:29 |
Publisher DOI: |
10.1371/journal.pone.0177059 |
PubMed ID: |
28489918 |
BORIS DOI: |
10.7892/boris.105554 |
URI: |
https://boris.unibe.ch/id/eprint/105554 |
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