Huang, Hairong; Wismeijer, Daniel; Hunziker, Ernst Bruno; Wu, Gang (2017). The Acute Inflammatory Response to Absorbed Collagen Sponge Is Not Enhanced by BMP-2. International journal of molecular sciences, 18(3) MDPI 10.3390/ijms18030498
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Absorbed collagen sponge (ACS)/bone morphogenetic protein-2 (BMP-2) are widely used in clinical practise for bone regeneration. However, the application of this product was found to be associated with a significant pro-inflammatory response, particularly in the early phase after implantation. This study aimed to clarify if the pro-inflammatory activities, associated with BMP-2 added to ACS, were related to the physical state of the carrier itself, i.e., a wet or a highly dehydrated state of the ACS, to the local degree of vascularisation and/or to local biomechanical factors. ACS (0.8 cm diameter)/BMP-2 were implanted subcutaneously in the back of 12 eight-week-old Sprague Dawley rats. Two days after surgery, the implanted materials were retrieved and analysed histologically and histomorphometrically. The acute inflammatory response following implantation of ACS was dependent of neither the presence or absence of BMP-2 nor the degree of vascularization in the surrounding tissue nor the hydration state (wet versus dry) of the ACS material at the time of implantation. Differential micro biomechanical factors operating at the implantation site appeared to have an influence on the thickness of inflammation. We conclude that the degree of the early inflammatory response of the ACS/BMP-2 may be associated with the physical and chemical properties of the carrier material itself.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Osteoporosis |
UniBE Contributor: |
Hunziker, Ernst Bruno |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1661-6596 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Romain Perrelet |
Date Deposited: |
11 Dec 2017 14:26 |
Last Modified: |
07 Aug 2024 15:45 |
Publisher DOI: |
10.3390/ijms18030498 |
PubMed ID: |
28245606 |
Uncontrolled Keywords: |
absorbed collagen sponge (ACS) biomechanical bone morphogenetic protein-2 (BMP-2) inflammation vascularization |
BORIS DOI: |
10.7892/boris.107114 |
URI: |
https://boris.unibe.ch/id/eprint/107114 |
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