Wierichs, R J; Zelck, H; Doerfer, C E; Appel, P; Paris, S; Esteves-Oliveira, M; Meyer-Lückel, Hendrik (2017). Effects of dentifrices differing in fluoride compounds on artificial enamel caries lesions in vitro. Odontology, 105(1), pp. 36-45. Springer 10.1007/s10266-016-0233-x
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The aim of this study was to compare the caries-preventive effect of a stabilized stannous fluoride/sodium fluoride dentifrice containing sodium hexametaphosphate with those of a regular, solely sodium fluoride-containing and amine fluoride-containing dentifrice on pre-demineralized bovine enamel specimens using a pH-cycling model. Bovine enamel specimens with two artificial lesions each were prepared. Baseline mineral loss of both lesions was analyzed using transversal microradiography (TMR). Eighty-five specimens with a mean (SD) baseline mineral loss of 3393 (683) vol% × µm were selected and randomly allocated to five groups (n = 13/15). Treatments during pH-cycling (28 days and 2 × 20 min demineralization/day) were: brushing twice daily with slurries of AmF (1400 ppm F-), NaF (1450 ppm F-), SnF2/NaF (1100 ppm F-/350 ppm F-), and fluoride-free (FF) dentifrices or they were immersed in distilled water and remained unbrushed (NB). Subsequently, from each specimen one lesion was covered with acid-resistant varnish, while the remaining lesion was demineralized for another 14 days. Differences in integrated mineral loss (∆∆Z) were calculated between values before and after pH-cycling (∆∆Z E1) as well as before pH-cycling and after second demineralization (∆∆Z E2) using TMR. Treatments AmF and NaF induced a significantly higher mineral gain (∆∆Z E1/∆∆Z E2) compared to treatments FF and NB (p < 0.05; ANOVA test). Except for treatments AmF and NaF no significant differences in mineral loss between before and after pH-cycling could be observed (p < 0.05; t test) [∆∆Z E1: AmF:1563 (767); NaF:1222 (1246); SnF2/NaF:258 (1259); FF:-52 (1223); NB:-151 (834)]. Both dentifrices with either AmF or NaF promoted remineralization, whereas SnF2/NaF dentifrice did not promote remineralization in a biofilm-free pH-cycling model.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry |
UniBE Contributor: |
Meyer-Lückel, Hendrik |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1618-1247 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Hendrik Meyer-Lückel |
Date Deposited: |
10 Jan 2018 16:10 |
Last Modified: |
05 Dec 2022 15:08 |
Publisher DOI: |
10.1007/s10266-016-0233-x |
PubMed ID: |
26849573 |
Uncontrolled Keywords: |
Amine fluoride Demineralization In vitro Sodium fluoride Stannous fluoride |
BORIS DOI: |
10.7892/boris.107817 |
URI: |
https://boris.unibe.ch/id/eprint/107817 |
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