Kallweit, Ulf; Bassetti, Claudio (2017). Pharmacological management of narcolepsy with and without cataplexy. Expert opinion on pharmacotherapy, 18(8), pp. 809-817. Informa Healthcare 10.1080/14656566.2017.1323877
Full text not available from this repository. (Request a copy)INTRODUCTION
Narcolepsy is an orphan neurological disease and presents with sleep-wake, motoric, neuropsychiatric and metabolic symptoms. Narcolepsy with cataplexy is most commonly caused by an immune-mediated process including genetic and environmental factors, resulting in the selective loss of hypocretin-producing neurons. Narcolepsy has a major impact on workableness and quality of life. Areas covered: This review provides an overview of the temporal available treatment options for narcolepsy (type 1 and 2) in adults, including authorization status by regulatory agencies. First- and second-line options are discussed as well as combination therapies. In addition, treatment options for frequent coexisting co-morbidities and different phenotypes of narcolepsy are presented. Finally, this review considers potential future management strategies. Non-pharmacological approaches are important in the management of narcolepsy but will not be covered in this review. Expert opinion: Concise evaluation of symptoms and type of narcolepsy, coexisting co-morbidities and patients´ distinct needs is mandatory in order to identify a suitable, individual pharmacological treatment. First-line options include Modafinil/Armodafinil (for excessive daytime sleepiness, EDS), Sodium Oxybate (for EDS and/with cataplexy), Pitolisant (for EDS and cataplexy) and Venlafaxine (for cataplexy (off-label) and co-morbid depression). New symptomatic and causal treatment most probably will be completed by hypocretin-replacement and immune-modifying strategies.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Kallweit, Ulf, Bassetti, Claudio L.A. |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1465-6566 |
Publisher: |
Informa Healthcare |
Language: |
English |
Submitter: |
Stefanie Hetzenecker |
Date Deposited: |
27 Feb 2018 12:48 |
Last Modified: |
02 Mar 2023 23:29 |
Publisher DOI: |
10.1080/14656566.2017.1323877 |
PubMed ID: |
28443381 |
Uncontrolled Keywords: |
Narcolepsy cataplexy co-morbidities excessive daytime sleepiness hypocretin management pharmacological treatment |
URI: |
https://boris.unibe.ch/id/eprint/107971 |
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