Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO).

Soffietti, Riccardo; Abacioglu, Ufuk; Baumert, Brigitta; Combs, Stephanie E; Kinhult, Sara; Kros, Johan M; Marosi, Christine; Metellus, Philippe; Radbruch, Alexander; Villa Freixa, Salvador S; Brada, Michael; Carapella, Carmine M; Preusser, Matthias; Le Rhun, Emilie; Rudà, Roberta; Tonn, Joerg C; Weber, Damien Charles; Weller, Michael (2017). Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO). Neuro-Oncology, 19(2), pp. 162-174. Oxford University Press 10.1093/neuonc/now241

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The management of patients with brain metastases has become a major issue due to the increasing frequency and complexity of the diagnostic and therapeutic approaches. In 2014, the European Association of Neuro-Oncology (EANO) created a multidisciplinary Task Force to draw evidence-based guidelines for patients with brain metastases from solid tumors. Here, we present these guidelines, which provide a consensus review of evidence and recommendations for diagnosis by neuroimaging and neuropathology, staging, prognostic factors, and different treatment options. Specifically, we addressed options such as surgery, stereotactic radiosurgery/stereotactic fractionated radiotherapy, whole-brain radiotherapy, chemotherapy and targeted therapy (with particular attention to brain metastases from non-small cell lung cancer, melanoma and breast and renal cancer), and supportive care.

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