Papadia, Andrea; Gasparri, Maria Luisa; Genoud, Sophie; Klaeser, Bernd; Mueller, Michael (2017). The combination of preoperative PET/CT and sentinel lymph node biopsy in the surgical management of early-stage cervical cancer. Journal of cancer research and clinical oncology, 143(11), pp. 2275-2281. Springer 10.1007/s00432-017-2467-6
|
Text
The combination of preoperative PETCT and sentinel lympf node biopsy in the surgical management of early stage cervical cancer_BK.pdf - Published Version Available under License Publisher holds Copyright. Download (396kB) | Preview |
INTRODUCTION
The aim of the study was to evaluate the use of PET/CT and/or SLN mapping alone or in combination in cervical cancer patients.
MATERIALS AND METHODS
Data on stage IA1-IIA cervical cancer patients undergoing PET/CT and SLN mapping were retrospectively collected. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of PET/CT and SLN mapping, alone or in combination, in identifying cervical cancer patients with lymph node metastases were calculated.
RESULTS
Sixty patients met the inclusion criteria. PET/CT showed a sensitivity of 68%, a specificity of 84%, a PPV of 61% and a NPV of 88% in detecting lymph nodal metastases. SLN mapping showed a sensitivity of 93%, a specificity of 100%, a PPV of 100% and a NPV of 97%. The combination of PET/CT and SLN mapping showed a sensitivity of 100%, a specificity of 86%, a PPV of 72% and a NPV of 100%. For patients with tumors of >2 cm in diameter, the PET/CT showed a sensitivity of 68%, a specificity of 72%, a PPV of 61% and a NPV of 86%. SLN mapping showed a sensitivity of 93%, a specificity of 100%, a PPV of 100% and a NPV of 95%. The combination of PET/CT and SLN mapping showed a sensitivity of 100%, a specificity of 76%, a PPV of 72% and a NPV of 100%.
CONCLUSION
PET/CT represents a "safety net" that helps the surgeon in identifying metastatic lymph nodes, especially in patients with larger tumors.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Papadia, Andrea, Genoud, Sophie, Klaeser, Bernd, Mueller, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-1335 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Franziska Nicoletti |
Date Deposited: |
07 Feb 2018 15:27 |
Last Modified: |
05 Dec 2022 15:09 |
Publisher DOI: |
10.1007/s00432-017-2467-6 |
PubMed ID: |
28669052 |
Uncontrolled Keywords: |
Cervical cancer Indocyanine green Laparoscopy Positron emission tomography Sentinel lymph node biopsy |
BORIS DOI: |
10.7892/boris.109336 |
URI: |
https://boris.unibe.ch/id/eprint/109336 |
Actions (login required)
 |
Edit item |