von Wolff, Michael; Stute, Petra; Eisenhut, Markus; Marti, Ulrich; Bitterlich, Norman; Bersinger, Nick A. (2017). Serum and follicular fluid testosterone concentrations do not correlate, questioning the impact of androgen supplementation on the follicular endocrine milieu. Reproductive biomedicine online, 35(5), pp. 616-623. Elsevier 10.1016/j.rbmo.2017.07.012
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Basic research into a possible link between serum and follicular fluid androgen concentrations to detemine whether androgen supplementation in low responders affects follicular endocrine milieu is still lacking. Ninety-seven women (aged 28-43 years) undergoing one natural IVF cycle without any hormone stimulation were analysed. Serum and follicular fluid were collected at the time of follicle aspiration, and the concentrations of LH, total testosterone, oestradiol, dehydroepiandrosterone and anti-Mullerian hormone (AMH) were determined. Serum LH (P = 0.003) and AMH (P = 0.026) concentrations, and follicular fluid AMH (P = 0.015) decreased with increasing age. Within follicular fluid, total testosterone was correlated with oestradiol (P < 0.001) and AMH (P = 0.010); LH correlated with AMH (P = 0.005). Correlation analysis of serum and follicular fluid hormone concentrations revealed that LH, oestradiol and AMH correlated (P < 0.001), whereas testosterone did not. Testosterone serum concentrations did not correlate with other follicular fluid hormones, such as dehydroepiandrosterone, oestradiol and AMH, whereas serum LH correlated with follicular flulid AMH (P < 0.008). Follicular fluid hormone concentrations seem to be independent from serum testosterone. Therefore, it is questionable whether an increase in serum testosterone concentration by androgen supplementation could improve the follicular endocrine milieu.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Endometrium & Ovar 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Endokrinologie der Brust |
UniBE Contributor: |
von Wolff, Michael, Stute, Petra, Eisenhut, Markus, Bersinger, Nick A. |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1472-6483 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Monika Zehr |
Date Deposited: |
29 Mar 2018 11:20 |
Last Modified: |
05 Dec 2022 15:10 |
Publisher DOI: |
10.1016/j.rbmo.2017.07.012 |
PubMed ID: |
28821386 |
Uncontrolled Keywords: |
Anti-Müllerian hormone Follicular fluid LH Natural cycle IVF Testosterone |
BORIS DOI: |
10.7892/boris.111084 |
URI: |
https://boris.unibe.ch/id/eprint/111084 |
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