Goldmann, Tobias; Wieghofer, Peter; Jordão, Marta Joana Costa; Prutek, Fabiola; Hagemeyer, Nora; Frenzel, Kathrin; Amann, Lukas; Staszewski, Ori; Kierdorf, Katrin; Krueger, Martin; Locatelli, Giuseppe; Hochgerner, Hannah; Zeiser, Robert; Epelman, Slava; Geissmann, Frederic; Priller, Josef; Rossi, Fabio M V; Bechmann, Ingo; Kerschensteiner, Martin; Linnarsson, Sten; ... (2016). Origin, fate and dynamics of macrophages at central nervous system interfaces. Nature immunology, 17(7), pp. 797-805. Nature Publishing Group 10.1038/ni.3423
Full text not available from this repository. (Request a copy)Perivascular, subdural meningeal and choroid plexus macrophages are non-parenchymal macrophages that mediate immune responses at brain boundaries. Although the origin of parenchymal microglia has recently been elucidated, much less is known about the precursors, the underlying transcriptional program and the dynamics of the other macrophages in the central nervous system (CNS). It was assumed that they have a high turnover from blood-borne monocytes. However, using parabiosis and fate-mapping approaches in mice, we found that CNS macrophages arose from hematopoietic precursors during embryonic development and established stable populations, with the notable exception of choroid plexus macrophages, which had dual origins and a shorter life span. The generation of CNS macrophages relied on the transcription factor PU.1, whereas the MYB, BATF3 and NR4A1 transcription factors were not required.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Locatelli, Giuseppe |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1529-2908 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Ursula Zingg-Zünd |
Date Deposited: |
22 Mar 2018 16:28 |
Last Modified: |
05 Dec 2022 15:10 |
Publisher DOI: |
10.1038/ni.3423 |
PubMed ID: |
27135602 |
URI: |
https://boris.unibe.ch/id/eprint/111243 |
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