Patterns of non-syndromic permanent tooth agenesis in a large orthodontic population

Gkantidis, Nikolaos; Katib, Hattan Saud A; Oeschger, Elias Sebastian; Karamolegkou, M; Topouzelis, N; Kanavakis, G (2017). Patterns of non-syndromic permanent tooth agenesis in a large orthodontic population. Archives of oral biology, 79, pp. 42-47. Elsevier Science 10.1016/j.archoralbio.2017.02.020

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OBJECTIVE:
The aim of this study is to explore patterns of non-syndromic permanent tooth agenesis in a large orthodontic patient group.
DESIGN:
A record review was performed in various orthodontic clinics to identify white patients with non-syndromic permanent tooth agenesis, excluding 3rd molars. Four hundred and fourteen subjects fulfilled the inclusion criteria.
RESULTS:
In the 414 subjects with tooth agenesis, approximately 70% presented 1-2 missing teeth. Symmetric agenesis patterns were often observed in the sample (by jaw, by side, or crossed quadrants), with prevalence approaching 30% for cases with contralateral tooth agenesis within a jaw. In cases with 1 or 2 missing teeth, from the total number of potential tooth agenesis patterns in the sample, a certain part was evident, limiting the variation to 27.8% (44/158). In the entire sample, both in the maxilla and the mandible a certain incisor/premolar agenesis phenotype was observed in 59.0% of cases in isolated form.
CONCLUSIONS:
Although there was variation in the tooth agenesis patterns, our findings suggest the involvement of particular genetic, epigenetic, and/or environmental factors in the formation of the entire dentition, which often lead to specific tooth agenesis phenotypes in cases where this process is disrupted. The present study provides a comprehensive categorization of orthodontic cases with tooth agenesis and can assist in planning future epidemiological and genetic studies.

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