Cerny, Andreas; Merino, Ramón; Fossati, Liliane; De Kossodo, Sylvie; Heusser, Christoph; Waldvogel, Francis A.; Morse, Herbert C.; Izui, Shozo (1992). Effect of Cyclosporin A and Zidovudine on Immune Abnormalities Observed in the Murine Acquired Immunodeficiency Syndrome. Journal of infectious diseases, 166(2), pp. 285-290. The University of Chicago Press 10.1093/infdis/166.2.285
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Two therapeutic modalities, zidovudine (targeting retroviral replication) and cyclosporin A (targeting immunopathologic consequences of retroviral expression) were evaluated in a murine model of AIDS. In previous studies, cyclosporin A treatment (40 or 60 mg/kg/day) before and after infection with LP-BM5 murine leukemia viruses protected against the development of immunodeficiency disease. The present study extends these findings. First, a low dose of cyclosporin A (20 mg/kg/day) was ineffective, and treatment initiated 5 days after infection did not protect against virus-induced lymphoproliferation and hypergammaglobulinemia. Second, zidovudine added to drinking water (0.1 mg initiated 5 days after infection and continued for 8 weeks) was more effective than 0.2 mg/ml, given day 5–12 after infection. This treatment reduced lymph node size, disease severity as determined histologically, retrovirus-induced gp70 expression, and IgE (but not IgM and IgG) levels. Third, combined treatment had an additive, protective effect on lymphocyte proliferative capacity. This successful dual therapeutic strategy in a mouse model has potential applicability for similar approaches in treating human immunodeficiency virus infection.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Clinical Pharmacology and Visceral Research [discontinued] |
UniBE Contributor: |
Cerny, Andreas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0022-1899 |
Publisher: |
The University of Chicago Press |
Language: |
English |
Submitter: |
Marceline Brodmann |
Date Deposited: |
08 Oct 2020 08:55 |
Last Modified: |
05 Dec 2022 15:13 |
Publisher DOI: |
10.1093/infdis/166.2.285 |
BORIS DOI: |
10.7892/boris.116091 |
URI: |
https://boris.unibe.ch/id/eprint/116091 |
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