Interventions to Improve Follow-up of Positive Results on Fecal Blood Tests: A Systematic Review.

Selby, Kevin; Baumgartner, Christine; Levin, Theodore R; Doubeni, Chyke A; Zauber, Ann G; Schottinger, Joanne; Jensen, Christopher D; Lee, Jeffrey K; Corley, Douglas A (2017). Interventions to Improve Follow-up of Positive Results on Fecal Blood Tests: A Systematic Review. Annals of internal medicine, 167(8), pp. 565-575. American College of Physicians 10.7326/M17-1361

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Background

Fecal immunochemical testing is the most commonly used method for colorectal cancer screening worldwide. However, its effectiveness is frequently undermined by failure to obtain follow-up colonoscopy after positive test results.

Purpose

To evaluate interventions to improve rates of follow-up colonoscopy for adults after a positive result on a fecal test (guaiac or immunochemical).

Data Sources

English-language studies from the Cochrane Central Register of Controlled Trials, PubMed, and Embase from database inception through June 2017.

Study Selection

Randomized and nonrandomized studies reporting an intervention for colonoscopy follow-up of asymptomatic adults with positive fecal test results.

Data Extraction

Two reviewers independently extracted data and ranked study quality; 2 rated overall strength of evidence for each category of study type.

Data Synthesis

Twenty-three studies were eligible for analysis, including 7 randomized and 16 nonrandomized studies. Three were at low risk of bias. Eleven studies described patient-level interventions (changes to invitation, provision of results or follow-up appointments, and patient navigators), 5 provider-level interventions (reminders or performance data), and 7 system-level interventions (automated referral, precolonoscopy telephone calls, patient registries, and quality improvement efforts). Moderate evidence supported patient navigators and provider reminders or performance data. Evidence for system-level interventions was low. Seventeen studies reported the proportion of test-positive patients who completed colonoscopy compared with a control population, with absolute differences of -7.4 percentage points (95% CI, -19 to 4.3 percentage points) to 25 percentage points (CI, 14 to 35 percentage points).

Limitation

More than half of studies were at high or very high risk of bias; heterogeneous study designs and characteristics precluded meta-analysis.

Conclusion

Patient navigators and giving providers reminders or performance data may help improve colonoscopy rates of asymptomatic adults with positive fecal blood test results. Current evidence about useful system-level interventions is scant and insufficient.

Primary Funding Source

National Cancer Institute. (PROSPERO: CRD42016048286).

Interest & Impact

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5 Citations in Web of Science ®
6 Citations in Scopus

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