Taghavi, Katayoun; Banerjee, Dipanwita; Mandal, Ranajit; Kallner, Helena Kopp; Thorsell, Malin; Friis, Therese; Kocoska-Maras, Ljiljana; Strander, Björn; Singer, Albert; Wikström, Elisabeth (2018). Colposcopy telemedicine: live versus static swede score and accuracy in detecting CIN2+, a cross-sectional pilot study. BMC women's health, 18(1), p. 89. BioMed Central 10.1186/s12905-018-0569-1
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BACKGROUND
This cross-sectional pilot study evaluates diagnostic accuracy of live colposcopy versus static image Swede-score evaluation for detecting significant precancerous cervical lesions greater than, or equal to grade 2 severity (CIN2+).
METHODS
VIA or HrHPV positive women were examined using a mobile colposcope, in a rural clinic in Kolkata, India. Live versus static Swede-score colposcopy assessments were made independently. All assessments were by gynecologists, junior or expert. Static image assessors were blinded to live scoring, patient information and final histopathology result. Primary outcome was the ability to detect CIN2+ lesions verified by directed biopsies. Diagnostic accuracy was calculated for live versus static Swede-score in detecting CIN2+ lesions, as well as for interclass correlation.
RESULTS
495 images from 94 VIA positive women were evaluated in this study. Thirteen women (13.9%) had CIN2+ on biopsy. No significant difference was found in the detection of CIN2+ lesions between live and static assessors (area under curve = 0.69 versus 0.71, p = 0.63). A Swede-score of 4+, had a sensitivity of 76.9% (95% CI 46.2-95.0%) and 84.6% (95% CI 54.6-98.1%), for live- and static-image assessment respectively. The corresponding positive predictive values were found to be 90.9% (95% CI 75.7-98.1%) and 92.6% (95% CI 75.7-99.1%). The interclass correlation was good (kappa statistic = 0.60) for the senior static assessors.
CONCLUSIONS
Swede-score evaluation of static colposcopy images was found to reliably detect CIN2+ lesions in this study. Larger studies are needed to further develop the colposcopy telemedicine concept which may offer reliable guidance in management where direct specialist input is not available.
TRIAL REGISTRATION
Ethical approval of the study was obtained by the Chittaranjan National Cancer Institute (CNCI) Human Research Ethics Committee (4.311/27/2014). The trial was retrospectively registered in the Clinical Trails Registry of India CTRI/2018/03/012470 .
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Taghavi, Katayoun |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1472-6874 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Tanya Karrer |
Date Deposited: |
21 Jun 2018 13:44 |
Last Modified: |
05 Dec 2022 15:14 |
Publisher DOI: |
10.1186/s12905-018-0569-1 |
PubMed ID: |
29890991 |
Uncontrolled Keywords: |
Cervical screening Colposcopy telemedicine Gynocular Low-resource settings Mobile colposcope |
BORIS DOI: |
10.7892/boris.117202 |
URI: |
https://boris.unibe.ch/id/eprint/117202 |
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