Yasinska, Inna M.; Ceccone, Giacomo; Ojea-Jimenez, Isaac; Ponti, Jessica; Hussain, Rohanah; Siligardi, Giuliano; Berger, Steffen M.; Fasler-Kan, Elizaveta; Bardelli, Marco; Varani, Luca; Fiedler, Walter; Wellbrock, Jasmin; Raap, Ulrike; Gibbs, Bernhard F.; Calzolai, Luigi; Sumbayev, Vadim V. (2018). Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates. Nanoscale, 10(13), pp. 5827-5833. Royal Society of Chemistry 10.1039/c7nr09436a
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In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Research Group Pediatric Surgery 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery |
UniBE Contributor: |
Berger, Steffen Michael, Fasler-Kan, Elizaveta |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2040-3364 |
Publisher: |
Royal Society of Chemistry |
Language: |
English |
Submitter: |
Christoph Steffen |
Date Deposited: |
26 Nov 2018 11:00 |
Last Modified: |
05 Dec 2022 15:17 |
Publisher DOI: |
10.1039/c7nr09436a |
PubMed ID: |
29538473 |
BORIS DOI: |
10.7892/boris.119583 |
URI: |
https://boris.unibe.ch/id/eprint/119583 |
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