Magnetization exchange with water and T(1) relaxation of the downfield resonances in human brain spectra at 3.0 T

Macmillan, Erin L; Chong, Daniel G Q; Dreher, Wolfgang; Henning, Anke; Boesch, Chris; Kreis, Roland (2011). Magnetization exchange with water and T(1) relaxation of the downfield resonances in human brain spectra at 3.0 T. Magnetic resonance in medicine, 65(5), pp. 1239-46. New York, N.Y.: Wiley-Liss 10.1002/mrm.22813

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The use of water suppression for in vivo proton MR spectroscopy diminishes the signal intensities from resonances that undergo magnetization exchange with water, particularly those downfield of water. To investigate these exchangeable resonances, an inversion transfer experiment was performed using the metabolite cycling technique for non-water-suppressed MR spectroscopy from a large brain voxel in 11 healthy volunteers at 3.0 T. The exchange rates of the most prominent peaks downfield of water were found to range from 0.5 to 8.9 s(-1), while the T(1) relaxation times in absence of exchange were found to range from 175 to 525 ms. These findings may help toward the assignments of the downfield resonances and a better understanding of the sources of contrast in chemical exchange saturation transfer imaging.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
UniBE Contributor:	Macmillan, Erin, Chong, Daniel, Boesch, Christoph Hans, Kreis, Roland
ISSN:	0740-3194
Publisher:	Wiley-Liss
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:09
Last Modified:	02 Mar 2023 23:20
Publisher DOI:	10.1002/mrm.22813
PubMed ID:	21394768
Web of Science ID:	000289760800005
URI:	https://boris.unibe.ch/id/eprint/1196 (FactScience: 202220)