Endocrine disrupting compounds: can they target the immune system of fish?

Casanova-Nakayama, A.; Wenger, M.; Burki, R.; Eppler, E.; Krasnov, A.; Segner, H. (2011). Endocrine disrupting compounds: can they target the immune system of fish? Marine pollution bulletin, 63(5-12), pp. 412-6. Oxford: Elsevier 10.1016/j.marpolbul.2011.05.007

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Endocrine disruption, in particular disruption by estrogen-active compounds, has been identified as an important ecotoxicological hazard in the aquatic environment. Research on the impact of endocrine disrupting compounds (EDCs) on wildlife has focused on disturbances of the reproductive system. However, there is increasing evidence that EDCs affect a variety of physiological systems other than the reproductive system. Here, we discuss if EDCs may be able to affect the immune system of fish, as this would have direct implications for individual fitness and population growth. Evidence suggesting an immunomodulatory role of estrogens in fish comes from the following findings: (a) estrogen receptors are expressed in piscine immune organs, (b) immune gene expression is modulated by estrogen exposure, and (c) pathogen susceptibility of fish increases under estrogen exposure.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute for Fish and Wildlife Health (FIWI) 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
UniBE Contributor:	Casanova, Ayako, Wenger, Michael, Segner, Helmut
Subjects:	600 Technology > 630 Agriculture
ISSN:	0025-326X
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:31
Last Modified:	05 Dec 2022 14:10
Publisher DOI:	10.1016/j.marpolbul.2011.05.007
Web of Science ID:	000294092700051
URI:	https://boris.unibe.ch/id/eprint/12074 (FactScience: 218352)