Cazzaniga, Simone; Ballmer-Weber, Barbara K; Gräni, Nora; Spring, Philippe; Bircher, Andreas; Anliker, Mark; Sonntag, Anne-Katharina; Piletta, Pierre; Huber, Caroline; Diepgen, Thomas L; Apfelbacher, Christian; Naldi, Luigi; Borradori, Luca; Simon, Dagmar (2018). Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement. Contact dermatitis, 79(3), pp. 136-148. Wiley-Blackwell 10.1111/cod.13041
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BACKGROUND
Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce.
OBJECTIVE
To evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2 years.
METHODS
Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses.
RESULTS
Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified.
CONCLUSIONS
Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Cazzaniga, Simone, Borradori, Luca, Simon, Dagmar |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0105-1873 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Andrea Studer-Gauch |
Date Deposited: |
30 Nov 2018 09:44 |
Last Modified: |
05 Dec 2022 15:21 |
Publisher DOI: |
10.1111/cod.13041 |
PubMed ID: |
29943397 |
Uncontrolled Keywords: |
CARPE chronic hand eczema clinical improvement epidemiology follow-up quality of life semantic map analysis |
BORIS DOI: |
10.7892/boris.121871 |
URI: |
https://boris.unibe.ch/id/eprint/121871 |
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