The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice.

Zimmermann, Jakob; Durek, Pawel; Kühl, Anja A; Schattenberg, Florian; Maschmeyer, Patrick; Siracusa, Francesco; Lehmann, Katrin; Westendorf, Kerstin; Weber, Melanie; Riedel, René; Müller, Susann; Radbruch, Andreas; Chang, Hyun-Dong (2018). The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice. European journal of immunology, 48(1), pp. 161-167. Wiley-VCH 10.1002/eji.201747100

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Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation.

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