Lionetti, Vincenzo; Cecchini, Marco; Ventura, Carlo (2011). Nanomechanics to drive stem cells in injured tissues: insights from current research and future perspectives. Stem cells and development, 20(4), pp. 561-8. Larchmont, N.Y.: Mary Ann Liebert 10.1089/scd.2010.0389
Full text not available from this repository.Stem cells reside within tissue, ensuring its natural ability to repair an injury. They are involved in the natural repair of damaged tissue, which encompasses a complex process requiring the modulation of cell survival, extracellular matrix turnover, angiogenesis, and reverse remodeling. To date, the real reparative potential of each tissue is underestimated and noncommittal. The assessment of the biophysical properties of the extracellular environment is an innovative approach to better understand mechanisms underlying stem cell function, and consequently to develop safe and effective therapeutic strategies replacing the loss of tissue. Recent studies have focused on the role played by biomechanical signals that drive stem cell death, differentiation, and paracrinicity in a genetic and/or an epigenetic manner. Mechanical stimuli acting on the shape can influence the biochemistry and gene expression of resident stem cells and, therefore, the magnitude of biological responses that promote the healing of injured tissue. Nanotechnologies have proven to be a revolutionary tool capable of dissecting the cellular mechanosensing apparatus, allowing the intercellular cross-talk to be decoded and enabling the reparative potential of tissue to be enhanced without manipulation of stem cells. This review highlights the most relevant findings of stem cell mechanobiology and presents a fascinating perspective in regenerative medicine.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology |
UniBE Contributor: |
Cecchini, Marco Giovanni |
ISSN: |
1547-3287 |
Publisher: |
Mary Ann Liebert |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:10 |
Last Modified: |
05 Dec 2022 14:00 |
Publisher DOI: |
10.1089/scd.2010.0389 |
PubMed ID: |
21034226 |
Web of Science ID: |
000289053000001 |
URI: |
https://boris.unibe.ch/id/eprint/1244 (FactScience: 202398) |
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