Classen, G.; Classen, C.; Bernasconi, Corrado Angelo; Brandt, C.; Gold, R.; Chan, Andrew; Hoepner, Robert (2019). Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy. Journal of neurovirology, 25(1), pp. 133-136. Springer 10.1007/s13365-018-0689-2
|
Text
Classen2019_Article_QuantitativeElectroencephalogr.pdf - Published Version Available under License Publisher holds Copyright. Download (503kB) | Preview |
Long-term treatment of multiple sclerosis with natalizumab (NTZ) carries the risk of a devastating complication in the form of an encephalopathy caused by a reactivation of a latent John Cunningham virus infection (progressive multifocal leucoencephalopathy, PML). Early diagnosis is associated with considerably better prognosis. Quantitative EEG as an objective, rater-independent technique provides high sensitivity (88) and specificity (82) for the diagnosis of NTZ-PML. Combination of diagnostic modalities addressing static morphological (brain MRI) as well as functional (EEG) pathologic changes may improve risk management programmes.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Bernasconi, Corrado Angelo, Chan, Andrew Hao-Kuang, Hoepner, Robert |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1538-2443 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Panagiota Milona |
Date Deposited: |
29 Mar 2019 13:34 |
Last Modified: |
02 Mar 2023 23:31 |
Publisher DOI: |
10.1007/s13365-018-0689-2 |
PubMed ID: |
30414049 |
Uncontrolled Keywords: |
Eeg John Cunningham virus encephalopathy Multiple sclerosis Natalizumab Pharmacovigilance Screening |
BORIS DOI: |
10.7892/boris.124668 |
URI: |
https://boris.unibe.ch/id/eprint/124668 |
Actions (login required)
 |
Edit item |