Real-life long-term effectiveness of fingolimod in Swiss patients with relapsing-remitting multiple sclerosis

Zecca, C.; Roth, S.; Findling, O.; Perriard, G.; Bachmann, V.; Pless, M. L.; Baumann, A.; Kamm, Christian Philipp; Lalive, P. H.; Czaplinski, A. (2018). Real-life long-term effectiveness of fingolimod in Swiss patients with relapsing-remitting multiple sclerosis. European journal of neurology, 25(5), pp. 762-767. Blackwell Science 10.1111/ene.13594

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BACKGROUND AND PURPOSE: In 2011, fingolimod was approved in Switzerland for the treatment of relapsing-remitting multiple sclerosis (RRMS). The aim of the present study was to assess the effectiveness and retention of fingolimod in a real-life Swiss setting, in which patients can receive fingolimod as both first- and second-line treatment for RRMS. METHODS: This cross-sectional, observational study with retrospective data collection was performed at 19 sites that comprised both hospitals and office-based physicians across Switzerland. Sites were asked to document eligible patients in consecutive chronological order to avoid selection bias. Demographic and clinical data from 274 consenting adult patients with RRMS who had received treatment with fingolimod were analyzed. RESULTS: Mean treatment duration with fingolimod was 32 months. Under fingolimod, 77.7 of patients remained free from relapses and 90.3 did not experience disability progression. The proportion of patients who were free from any clinical disease activity, i.e. without relapses and disability progression, was 72.1. A total of 28.5 of patients had been RRMS treatment-naive prior to fingolimod therapy. High long-term treatment retention rates ranging between 95.7 at 24 months and 87.8 at 36 months were observed. CONCLUSION: In this Swiss cohort of naive and pre-treated subjects with RRMS, the majority of patients under fingolimod treatment showed freedom from relapses and disability progression. In addition, treatment retention rate over 2 and 3 years was high, irrespective of previous treatment.

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