Nilius, Verena; Killer, Madeleine C; Timmesfeld, Nina; Schmitt, Melina; Moll, Roland; Lorch, Anja; Beyer, Jörg; Mack, Elisabeth; Lohoff, Michael; Burchert, Andreas; Neubauer, Andreas; Brendel, Cornelia (2018). High β-1,4-Galactosyltransferase-I expression in peripheral T-lymphocytes is associated with a low risk of relapse in germ-cell cancer patients receiving high-dose chemotherapy with autologous stem cell reinfusion. Oncoimmunology, 7(5), e1423169. Taylor & Francis 10.1080/2162402X.2017.1423169
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Survival of patients with germ-cell cancer (GCC) and primary progression or relapse after cisplatin-based first-line chemotherapy is highly heterogeneous, ranging from close to zero to more than 70%. We investigated β-1,4-Galactosyltransferase-I () expression levels in peripheral lymphocytes in a cohort of 46 testicular cancer patients. enhances immune cell crosstalk via glycosylation of surface molecules. A high expression level of in T-lymphocytes, but not in monocytes, was associated with a lower risk of relapse with a hazard ratio (HR) of 0.66 (95% confidence interval (CI) of HR: 0.45-0.97; = 0.02) upon multivariate Cox regression analysis. Correspondingly, interleukin 10 (IL10), a cytokine released by cytotoxic T-cells, was likewise significantly elevated in T-lymphocytes of non-relapse GCC patients (HR: 0.3; 95% CI of HR: 0.14-0.65; = 0.002). Our data indicate that glycosylation and activation of T-lymphocytes may play a pivotal role in disease control in GCC patients with primary progressive or relapsed disease.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Beyer, Jörg |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2162-4011 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Rebeka Gerber |
Date Deposited: |
19 Mar 2019 13:53 |
Last Modified: |
05 Dec 2022 15:25 |
Publisher DOI: |
10.1080/2162402X.2017.1423169 |
PubMed ID: |
29721375 |
Uncontrolled Keywords: |
B4GALT1 T-lymphocytes biomarker germ-cell cancer immunosurveillance |
BORIS DOI: |
10.7892/boris.124935 |
URI: |
https://boris.unibe.ch/id/eprint/124935 |
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