Fischinger, Isaak; Seiler, Theo G.; Santhirasegaram, Karthiga; Pettenkofer, Moritz; Lohmann, Chris P; Zapp, Daniel (2018). Corneal crosslinking (CXL) with 18-mW/cm irradiance and 5.4-J/cm radiant exposure-early postoperative safety. Graefe's archive for clinical and experimental ophthalmology, 256(8), pp. 1521-1525. Springer 10.1007/s00417-018-3978-9
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PURPOSE
To investigate safety of accelerated corneal crosslinking during the first postoperative month.
METHODS
In this retrospective study, 76 eyes of 60 patients with verified progressive keratectasia were enrolled in this study and followed for 1 month after accelerated CXL (18 mW/cm for 5 min, radiant exposure 5.4 J/cm) (A-CXL(5*18)). Preoperatively, objective refraction, slit lamp inspection, and corneal tomography were performed. Early postoperative slit lamp examinations were performed on days 1 and 4. At 1 month, objective refraction, slit lamp inspection, and corneal tomography were performed.
RESULTS
Gender distribution was m:f = 55:21, OD:OS was 40:36, and the average age was 26.5 ± 8.6 years at surgery. Only 71 of the 76 eyes completed the 1-month follow-up, indicating a dropout rate of 6.6%. In 7.0% (n = 5), sterile infiltrates were observed; 5.6% of eyes (n = 4) showed delayed epithelial healing (> 4 days) in 2.8% (n = 2); an infection occurred and in 1 eye (1.4%), a stromal scar was detected; no other complications, neither a loss of two or more Snellen lines at 1 month postoperatively, were observed. As a risk factor for sterile infiltrates, thin preoperative pachymetry could be identified (p = 0.027).
CONCLUSIONS
This study revealed no difference in early postoperative safety between CXL using 18 mW/cm and standard corneal CXL. Thinner preoperative pachymetry could be identified predicting a higher rate of postoperative sterile infiltrates.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Fischinger, Isaak, Seiler, Günter Theodor Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0721-832X |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Günter Theodor Michael Seiler |
Date Deposited: |
07 Mar 2019 16:20 |
Last Modified: |
05 Dec 2022 15:26 |
Publisher DOI: |
10.1007/s00417-018-3978-9 |
PubMed ID: |
29666915 |
Uncontrolled Keywords: |
18 mW Accelerated crosslinking Corneal crosslinking Keratectasia Keratokonus Sterile infiltrate |
BORIS DOI: |
10.7892/boris.125872 |
URI: |
https://boris.unibe.ch/id/eprint/125872 |
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