von Wolff, Michael; Bruckner, T; Strowitzki, T; Germeyer, A (2018). Fertility preservation: ovarian response to freeze oocytes is not affected by different malignant diseases-an analysis of 992 stimulations. Journal of assisted reproduction and genetics, 35(9), pp. 1713-1719. Springer 10.1007/s10815-018-1227-0
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PURPOSE
To study if ovarian response is affected by the type of disease if fertility preservation is required.
METHODS
A registry of the trinational fertility preservation network FertiPROTEKT including 992 patients aged 18-40 years undergoing ovarian stimulation and follicle aspiration for fertility preservation from 1/2007 until 3/2016 was analysed. The number of collected oocytes, days of stimulation, total gonadotropin dosage and gonadotropin dosage per day were evaluated.
RESULTS
Total oocyte number was negatively correlated with increasing age (r = 0.237, p < 0.0001). Oocyte numbers were in women < 26 years 15.4 ± 8.8, 26-30 years 13.1 ± 8.5, 31-35 years 12.2 ± 7.7 and 36-40 years 9.9 ± 8.0. Age-adjusted oocyte numbers were not different in women with Hodgkin's lymphoma (12.6 ± 8.8), non-Hodgkin's lymphoma (12.4 ± 8.2), leukaemia (11.7 ± 8.2), sarcoma (11.8 ± 8.2), cerebral cancer (16.5 ± 8.1), gastrointestinal cancer (13.2 ± 8.1) gynaecological cancer (10.8 ± 8.2) and other types of malignancies (15.8 ± 8.1) apart from ovarian cancer with lower oocyte yield (7.3 ± 8.3, p < 0.001) compared to women with breast cancer (13.3 ± 8.8). The total gonadotropin dose used for stimulation was only elevated in Hodgkin's and non-Hodgkin's lymphoma compared to women with breast cancer (p < 0.05). Oocyte yield was lower in women with versus without ovarian cancer (p < 0.0001).
CONCLUSIONS
As ovarian response is not affected by the type of cancer, ovarian stimulation can be performed with the same oocyte yield in different malignant diseases. However, oocyte yield is reduced if ovarian surgery is required and in older women.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
von Wolff, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1058-0468 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Monika Zehr |
Date Deposited: |
08 Apr 2019 15:45 |
Last Modified: |
05 Dec 2022 15:26 |
Publisher DOI: |
10.1007/s10815-018-1227-0 |
PubMed ID: |
29869766 |
Uncontrolled Keywords: |
Breast cancer Fertility preservation Hodgkin’s lymphoma Oocyte Ovarian cancer Ovarian stimulation |
BORIS DOI: |
10.7892/boris.126027 |
URI: |
https://boris.unibe.ch/id/eprint/126027 |
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