Zannin, Emanuela; Nyilas, Sylvia; Ramsey, Kathryn A.; Latzin, Philipp; Dellaca', Raffaele L (2019). Within-breath changes in respiratory system impedance in children with cystic fibrosis. Pediatric pulmonology, 54(6), pp. 737-742. Wiley-Blackwell 10.1002/ppul.24281
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BACKGROUND
The aim of this study was to assess within-breath respiratory system impedance by the forced oscillation technique (FOT) in children with cystic fibrosis (CF) and relate it to the underlying lung disease.
METHODS
Thirty-three children with CF (median [range] age 12.0 [6-17] years) underwent FOT at 8 Hz during tidal breathing, multiple breath nitrogen washout (LCI), spirometry (FEV1), body plethysmography (RV/TLC), and magnetic resonance imaging (MRI). FOT outcomes included: mean inspiratory, expiratory, and whole breath resistance (R8 , R8 , R8 ) and reactance (X8 , X8 , X8 ), and the differences between X8 and X8 (ΔX8). Morphological changes were evaluated by MRI using CF-specific morphological scores. Spearman correlation was performed to examine the correlation between FOT indices and other parameters.
RESULTS
FEV1 was negatively correlated with R8 (r = -0.52, P = 0.002) and ΔX8 (r = -0.55, P = 0.001), and positively correlated with and X8 (r = 0.56, P < 0.001). RV/TLC was positively correlated with R8 (r = 0.43, P = 0.013), and ΔX8 (r = 0.54, P = 0.001) and negatively correlated with X8 (r = -0.54, P = 0.001). We found poor correlation between FOT parameters and LCI and no correlation between FOT parameters and MRI scores.
CONCLUSION
In children with CF, changes in within-breath FOT parameters are consistent with peripheral obstruction and dynamic airway compression, while they are not associated with ventilation heterogeneities and morphological alterations.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Nyilas, Sylvia Meryl, Ramsey, Kathryn Angela, Latzin, Philipp |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
8755-6863 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
25 Apr 2019 10:30 |
Last Modified: |
05 Dec 2022 15:27 |
Publisher DOI: |
10.1002/ppul.24281 |
PubMed ID: |
30828997 |
Uncontrolled Keywords: |
cystic fibrosis respiratory system impedance within-breath forced oscillation technique |
BORIS DOI: |
10.7892/boris.127470 |
URI: |
https://boris.unibe.ch/id/eprint/127470 |
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