Schmid, V.B.; Spreng, David; Seewald, W.; Jung, M.; Lees, P.; King, J.N. (2010). Analgesic and anti-inflammatory actions of robenacoxib in acute joint inflammation in dog. Journal of veterinary pharmacology and therapeutics, 33(2), pp. 118-31. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2885.2009.01117.x
Full text not available from this repository. (Request a copy)The objectives of this study were to establish dose-response and blood concentration-response relationships for robenacoxib, a novel nonsteroidal anti-inflammatory drug with selectivity for inhibition of the cyclooxygenase (COX)-2 isoenzyme, in a canine model of synovitis. Acute synovitis of the stifle joint was induced by intra-articular injection of sodium urate crystals. Robenacoxib (0.25, 0.5, 1.0, 2.0 and 4.0 mg/kg), placebo and meloxicam (0.2 mg/kg) were administered subcutaneously (s.c.) 3 h after the urate crystals. Pharmacodynamic endpoints included data from forceplate analyses, clinical orthopaedic examinations and time course of inhibition of COX-1 and COX-2 in ex vivo whole blood assays. Blood was collected for pharmacokinetics. Robenacoxib produced dose-related improvement in weight-bearing, pain and swelling as assessed objectively by forceplate analysis (estimated ED(50) was 1.23 mg/kg for z peak force) and subjectively by clinical orthopaedic assessments. The analgesic and anti-inflammatory effects of robenacoxib were significantly superior to placebo (0.25-4 mg/kg robenacoxib) and were non-inferior to meloxicam (0.5-4 mg/kg robenacoxib). All dosages of robenacoxib produced significant dose-related inhibition of COX-2 (estimated ED(50) was 0.52 mg/kg) but no inhibition of COX-1. At a dosage of 1-2 mg/kg administered s.c., robenacoxib should be at least as effective as 0.2 mg/kg of meloxicam in suppressing acute joint pain and inflammation in dogs.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic |
UniBE Contributor: |
Spreng, David Emmanuel |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
0140-7783 |
Publisher: |
Blackwell Scientific Publications |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:33 |
Last Modified: |
02 Mar 2023 23:21 |
Publisher DOI: |
10.1111/j.1365-2885.2009.01117.x |
Web of Science ID: |
000275334000002 |
URI: |
https://boris.unibe.ch/id/eprint/12807 (FactScience: 219281) |
Actions (login required)
 |
Edit item |