Childhood brain tumours, early infections and immune stimulation: A pooled analysis of the ESCALE and ESTELLE case-control studies (SFCE, France).

Lupatsch, Judith E; Bailey, Helen D; Lacour, Brigitte; Dufour, Christelle; Bertozzi, Anne-Isabelle; Leblond, Pierre; Faure-Conter, Cécile; Pellier, Isabelle; Freycon, Claire; Doz, François; Puget, Stéphanie; Ducassou, Stéphane; Orsi, Laurent; Clavel, Jacqueline (2018). Childhood brain tumours, early infections and immune stimulation: A pooled analysis of the ESCALE and ESTELLE case-control studies (SFCE, France). Cancer epidemiology, 52, pp. 1-9. Elsevier 10.1016/j.canep.2017.10.015

	Text Lupatsch CancerEpidemiol 2018.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (164kB)
Preview	Text Lupatsch CancerEpidemiol 2018_postprint.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (467kB) | Preview

BACKGROUND

Few studies have investigated whether early infections and factors potentially related to early immune stimulation might be involved in the aetiology of childhood brain tumours (CBT). In this study, we investigated the associations between CBT with early day-care attendance, history of early common infections, atopic conditions (asthma/wheezing, eczema, allergic rhinitis), early farm residence/visits and contact with animals.

METHODS

We pooled data from two nationwide French case-control studies, the ESCALE and ESTELLE studies. Children with a CBT diagnosed between 1 and 14 years of age were identified directly from the French National Registry of Childhood Cancers, while population controls were recruited from telephone subscribers. Odds-ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression adjusted for potential confounders.

RESULTS

The analyses included 469 cases and 2719 controls. We found no association between attending a day-care centre (OR: 0.9, 95%CI: 0.7-1.2) or having had repeated common infections (OR: 0.9, 95%CI: 0.7-1.2) in the first year of life and the risk of CBT. There was also no association with a history of asthma/wheezing (OR: 0.8, 95%CI: 0.56-1.1). Farm visits (OR: 0.6, 95%CI: 0.5-0.8) as well as contact with pets (OR: 0.8, 95%CI: 0.6-1.0) in the first year of life were inversely associated with CBT.

CONCLUSIONS

Our findings suggest a protective effect of early farm visits and contact with pets, but not with other markers of early immune stimulation. This might be related to immune stimulation but needs further investigation.

Interest & Impact

Downloads

234 since deposited on 09 May 2019
12 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item