The nuclear envelope--a scaffold for silencing?

Towbin, Benjamin D; Meister, Peter; Gasser, Susan M (2009). The nuclear envelope--a scaffold for silencing? Current opinion in genetics & development, 19(2), pp. 180-186. Elsevier 10.1016/j.gde.2009.01.006

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An increasing number of studies indicate that chromosomes are spatially organized in the interphase nucleus and that some genes tend to occupy characteristic zones of the nuclear volume. FISH studies in mammalian cells suggest a differential localization of active and inactive loci, with inactive heterochromatin being largely perinuclear. Recent genome-wide mapping techniques confirm that the nuclear lamina, which lies beneath the nuclear envelope, interacts preferentially with silent genes. To address the functional significance of spatial compartmentation, gain-of-function assays in which chromatin is targeted to the nuclear periphery have now been carried out. Such experiments yielded coherent models in yeast; however, conflicting results in mammalian cells leave it unclear whether these concepts apply to higher organisms. Nevertheless, the recent discovery that evolutionarily conserved inner nuclear membrane proteins support the peripheral anchoring of yeast heterochromatin suggests that certain principles of nuclear organization may hold true from yeast to man.

Item Type:	Journal Article (Review Article)
Division/Institute:	08 Faculty of Science > Department of Biology > Institute of Cell Biology
UniBE Contributor:	Towbin, Benjamin Daniel
Subjects:	500 Science > 570 Life sciences; biology
ISSN:	0959-437X
Publisher:	Elsevier
Language:	English
Submitter:	Benjamin Daniel Towbin
Date Deposited:	26 Nov 2020 15:11
Last Modified:	05 Dec 2022 15:28
Publisher DOI:	10.1016/j.gde.2009.01.006
PubMed ID:	19303765
URI:	https://boris.unibe.ch/id/eprint/130612