Meinel, Thomas Raphael; Kaesmacher, Johannes; Chaloulos-Iakovidis, Panagiotis; Panos, Leonidas; Mordasini, Pasquale; Mosimann, Pascal John; Michel, Patrik; Hajdu, Steven; Ribo, Marc; Requena, Manuel; Maegerlein, Christian; Friedrich, Benjamin; Costalat, V; Benali, Amel; Pierot, Laurent; Gawlitza, Matthias; Schaafsma, Joanna; Pereira, Vitor M; Gralla, Jan and Fischer, Urs (2019). Mechanical thrombectomy for basilar artery occlusion: efficacy, outcomes, and futile recanalization in comparison with the anterior circulation. Journal of neurointerventional surgery, 11(12), pp. 1174-1180. BMJ Publishing Group 10.1136/neurintsurg-2018-014516
|
Text
mechanical_kaesmacher.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (558kB) | Preview |
BACKGROUND
Performing mechanical thrombectomy (MT) in patients with basilar artery occlusion (BAO) is currently not evidence-based.
OBJECTIVE
To compare patients' outcome, relative merits of achieving recanalization, and predictors of futile recanalization (FR) between BAO and anterior circulation large vessel occlusion (ACLVO) MT.
METHODS
In the multicenter BEYOND-SWIFT registry (NCT03496064), univariate and multivariate (displayed as adjusted Odds Ratios, aOR and 95% confidence intervals, 95%-CI) outcome comparisons between BAO (N=165) and ACLVO (N=1574) were performed. The primary outcome was favorable outcome at 90 days (modified Rankin Scale, mRS 0-2). Secondary outcome included mortality, symptomatic intracranial hemorrhage (sICH) and FR. The relative merits of achieving successful recanalization between ACLVO and BAO were evaluated with interaction terms.
RESULTS
MT in BAO was more often technically effective and equally safe in regards to mortality and sICH when compared to ACLVO. When adjusting for baseline differences, there was no significant difference between BAO vs ACLVO regarding rates of favorable outcome (aOR 0.986, 95%-CI 0.553 - 1.758). However, BAO were associated with increased rates of FR (aOR 2.146, 95%-CI 1.267 - 3.633). Predictors for FR were age, stroke severity, maneuver count and intracranial stenting. No significant heterogeneity on the relative merits of achieving successful recanalization on several outcome parameters were observed when comparing BAO and ACLVO.
CONCLUSIONS
In selected patients, similar outcomes can be achieved in BAO and ACLVO patients treated with MT. Randomized controlled trials comparing patient selection and interventional strategies seem warranted to avoid FR.
TRIAL REGISTRATION NUMBER
NCT03496064.
Actions (login required)
 |
Edit item |