Comparison of systemic exposure to toxic and/or carcinogenic volatile organic compounds (VOCs) during vaping, smoking, and abstention.

St Helen, Gideon; Liakoni, Evangelia; Nardone, Natalie; Addo, Newton; Jacob, Peyton; Benowitz, Neal L (2020). Comparison of systemic exposure to toxic and/or carcinogenic volatile organic compounds (VOCs) during vaping, smoking, and abstention. Cancer prevention research, 13(2), pp. 153-162. AACR 10.1158/1940-6207.CAPR-19-0356

[img]
Preview
Text
St. Helen. VOC Ecig crossover.CA Prev 2019.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (1MB) | Preview
[img] Text
St. Helen. VOC Ecig crossover.CA Prev 2019.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (680kB)

Comparisons of systemic exposure to toxicants during monitored cigarette smoking, electronic cigarette (e-cigarette) use and abstention are needed to enhance our understanding of the risks of e-cigarette use (vaping). In a crossover study, we measured 10 mercapturic acid metabolites of volatile organic compounds (VOCs) in 24-h urine samples collected from 36 dual users (8 women) of e-cigarettes and cigarettes during two days of ad libitum vaping or cigarette-only use, and two days of enforced abstention. Concentrations of VOC metabolites were higher during smoking compared to vaping, except for the methylating agents metabolite. The fold-difference in concentrations when smoking relative to vaping ranged from 1.31 (1.06-1.61) (GM, 95% CI) (1,3-butadiene) to 7.09 (5.88-8.54) (acrylonitrile). Metabolites of acrylamide [fold difference of 1.21 (1.03-1.43)] and benzene [1.46 (1.13-1.90)] were higher during vaping compared to abstention. The 1,3-butadiene and propylene oxide metabolites were higher in variable-power tank users compared to users of cig-a-likes. E-cigarettes expose users to lower levels of toxic VOCs compared to cigarette smoking, supporting their harm reduction potential among smokers. However, some e-cigarettes expose users to VOCs such as acrylamide, benzene, and propylene oxide, and may pose health risks to nonsmoking users. The results of our study will inform regulators in assessing e-cigarettes with respect to the balance between its potential harm reduction for adult smokers and risk to nonsmoking users.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Liakoni, Evangelia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1940-6215

Publisher:

AACR

Language:

English

Submitter:

Tobias Tritschler

Date Deposited:

14 Oct 2019 13:18

Last Modified:

05 Dec 2022 15:31

Publisher DOI:

10.1158/1940-6207.CAPR-19-0356

PubMed ID:

31554628

BORIS DOI:

10.7892/boris.133866

URI:

https://boris.unibe.ch/id/eprint/133866

Actions (login required)

Edit item Edit item
Provide Feedback