Pattern of failure after adjuvant radiotherapy following extrapleural pneumonectomy of pleural mesothelioma in the SAKK 17/04 trial.

Riesterer, Oliver; Frank Ciernik, I; Stahel, Rolf A; Xyrafas, Alexandros; Aebersold, Daniel; Plasswilm, Ludwig; Mahmut Ozsahin, E; Zwahlen, Daniel R; Nackaerts, Kristiaan; Zimmermann, Frank; Sabrina Stark, L; Weder, Walter; Krayenbuehl, Jérôme (2019). Pattern of failure after adjuvant radiotherapy following extrapleural pneumonectomy of pleural mesothelioma in the SAKK 17/04 trial. Radiotherapy and oncology, 138, pp. 121-125. Elsevier 10.1016/j.radonc.2019.05.024

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Postoperative radiotherapy after extrapleural pneumonectomy of malignant pleural mesothelioma was investigated in the randomized phase II trial SAKK17/04. The relapse rate within the high and/or low-dose PTV without previous distant failure was 24%, the isolated in-field-relapse rate within the PTVs was 5% and the distant relapse rate outside of the PTVs was 81%. Clinical outcome was mainly determined by distant disease progression outside of the radiation field.

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