Spano, Giancarlo; Stutz, Emanuel; Eliçin, Olgun; Hugi, Beate; Henzen, Dominik; Fürholz, Monika; Wieser, Monika; Rhyner, Daniel Kaspar; Dobner, Stephan; Pavlicek-Bahlo, Maryam; Robson, Desiree; Nadel, James; Hayward, Christopher; Hunziker, Lukas; Martinelli, Michele; Schnegg, Bruno (2020). Is It Safe to Irradiate the Newest Generation of Ventricular Assist Devices? A Case Report and Systematic Literature Review. Artificial organs, 44(5), pp. 449-456. Wiley-Blackwell 10.1111/aor.13612
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Spano_et_al-2019-Artificial_Organs.pdf - Accepted Version Available under License Publisher holds Copyright. Download (11MB) | Preview |
An increasing number of mechanical assist devices, especially Left Ventricular Assist Devices (VAD), are being implanted for prolonged periods and as destination therapy. Some VAD patients require radiotherapy due to concomitant oncologic morbidities, including thoracic malignancies. This raises the potential of VAD malfunction via radiation-induced damage. So far, only case reports and small case series on radiotherapy have been published; most of them on HeartMate IITM (HMII, Abbott, North Chicago, IL, USA). Significantly, the effects of irradiation on the HeartMate 3TM (HM3, Abbott, North Chicago, IL, USA) remain undefined, despite the presence of controller components engineered within the pump itself. We report the first case of a patient with a HM3 who successfully underwent stereotactic hypo-fractionated radiotherapy due to an early stage non-small-cell lung cancer. The patient did not suffer from any complications; including toxicity or VAD malfunction. Based on this case report and on published literature, we think that performing radiotherapy after VAD implantation with the aid of a multidisciplinary team could be performed, but more in-vitro and cases series are needed to reinforce this statement.
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