CAN MICROWAVE ABLATION BE AN ALTERNATIVE TO RESECTION FOR THE TREATMENT OF NEUROENDOCRINE LIVER METASTASES?

Perrodin, Stéphanie F.; Renzulli, Mariko M.; Maurer, Martin H.; Kim-Fuchs, Corina; Candinas, Daniel; Beldi, Guido; Lachenmayer, Anja (2020). CAN MICROWAVE ABLATION BE AN ALTERNATIVE TO RESECTION FOR THE TREATMENT OF NEUROENDOCRINE LIVER METASTASES? Endocrine practice, 26(4), pp. 378-387. AACE 10.4158/EP-2019-0394

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OBJECTIVES

Surgical resection of neuroendocrine tumor liver metastases has been proven to improve survival, but the benefit of microwave ablation as an alternative or adjunct to surgery has yet to be assessed. Our hypothesis is that ablation is equal to surgery in terms of local recurrence and survival.

METHODS

We conducted a retrospective analysis including all patients treated with microwave ablation and/or surgical resection for neuroendocrine liver metastases in our institution between 2008 and 2017.

RESULTS

A total of 47 patients and 68 treatments were analyzed, including 34 liver resections, 20 ablations, and 14 combined procedures. A total of 130 individual metastases were treated with ablation, representing median 4 per session (1-30). While no major complications occurred after ablation, we observed 11 minor and 3 major complications after open surgical resection (p=0.0135). Length of stay was significantly shorter after ablation (p=0.0008). The majority of patients (33/47, 70.2%) underwent curative procedures, 14 patients (29.8%) debulking procedures. There was no difference in local recurrence rate between tumors treated with ablation or resection. Liver-only disease progression was detected in 29% of the patients and overall progression in 66%. The mean survival was not significantly different between patients treated with ablation only versus resection with or without ablation (p = 0.1570). Overall survival was mean 75.3 months (6 to 374 months).

CONCLUSION

Depending on the extent of the liver metastases, microwave ablation might be a safe alternative or addition to resection for neuroendocrine tumor liver metastases with low morbidity and high local efficiency.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

 Perrodin, Stéphanie Fabienne, Maurer, Martin, Kim-Fuchs, Corina, Candinas, Daniel, Beldi, Guido Jakob Friedrich, Lachenmayer, Anja

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 1530-891X

Publisher:

 AACE

Language:

 English

Submitter:

 Maria de Fatima Henriques Bernardo

Date Deposited:

 23 Jan 2020 14:43

Last Modified:

 05 Dec 2022 15:34

Publisher DOI:

 10.4158/EP-2019-0394

PubMed ID:

 31859556

BORIS DOI:

 10.7892/boris.137470

URI:

 https://boris.unibe.ch/id/eprint/137470

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