Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

Kindler, Jochen; Lim, Chai K.; Weickert, Cynthia Shannon; Boerrigter, Danny; Galletly, Cherrie; Liu, Dennis; Jacobs, Kelly R.; Balzan, Ryan; Bruggemann, Jason; O’Donnell, Maryanne; Lenroot, Rhoshel; Guillemin, Gilles J.; Weickert, Thomas W. (2020). Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia. Molecular psychiatry, 25(11), pp. 2860-2872. Springer Nature 10.1038/s41380-019-0401-9

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Etiological models of eating disorders (EDs) describe body dissatisfaction (BD) as one of the major influences fostering dysfunctional body-related behavior and disordered eating behavior. BD is influenced by repeated exposure to thin ideals that evoke high self-ideal discrepancy and result in body-related cognitive distortions such as thought-shape fusion body (TSF-B). The aim of the study was to investigate the covariation of daily media exposure and the experience of TSF-B in a naturalistic setting. It was further analyzed whether TSF-B is associated with self-ideal discrepancy, dysfunctional body-related behavior and disordered eating behavior. Moreover, person-related predictors of TSF-B were explored. Altogether 51 healthy female students (mean age 21.06 years, SD=1.76) participated in an ecological momentary assessment study with 4 daily surveys during 10 consecutive days. Exposure with thin ideals in contrast to exposure to unspecific media contents went along with the experience of TSF-B. TSF-B was associated with higher self-ideal discrepancy, dysfunctional body-related behavior as well as more pronounced disordered eating behavior, suggesting that TSF-B is a common phenomenon in young healthy females' everyday life. A main effect of trait measures (e.g. preexisting BD) on TSF-B was observable, but no moderating effect. Thus, a specific vulnerability has not been detected.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division

UniBE Contributor:

Kindler, Jochen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1359-4184

Publisher:

Springer Nature

Language:

English

Submitter:

Chantal Michel

Date Deposited:

28 Jan 2020 09:33

Last Modified:

05 Dec 2022 15:35

Publisher DOI:

10.1038/s41380-019-0401-9

PubMed ID:

30940904

BORIS DOI:

10.7892/boris.138441

URI:

https://boris.unibe.ch/id/eprint/138441

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