Stent Thrombosis in Patients with Atrial Fibrillation Undergoing Coronary Stenting in the AUGUSTUS Trial.

Lopes, Renato D; Leonardi, Sergio; Wojdyla, Daniel M; Vora, Amit N; Thomas, Laine; Storey, Robert F; Vinereanu, Dragos; Granger, Christopher B; Goodman, Shaun G; Aronson, Ronald; Windecker, Stephan; Thiele, Holger; Valgimigli, Marco; Mehran, Roxana; Alexander, John H (2020). Stent Thrombosis in Patients with Atrial Fibrillation Undergoing Coronary Stenting in the AUGUSTUS Trial. Circulation, 141(9), pp. 781-783. American Heart Association 10.1161/CIRCULATIONAHA.119.044584

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We describe the incidence, timing, and characteristics of stent thrombosis and its consequences in patients with atrial fibrillation (AF) in the AUGUSTUS trial1 who received a coronary stent during their qualifying admission (acute coronary syndrome [ACS] or elective percutaneous coronary intervention [PCI]) and the randomized treatment effects of low-dose aspirin (compared with placebo) and apixaban (compared with vitamin K antagonist [VKA]) on the risk of stent thrombosis. We included patients who received a stent during their qualifying admission. We excluded patients with medically-managed ACS (n=1097) or an unknown qualifying index event (n=19). The protocol was approved by appropriate ethics committees; patients provided written informed consent prior to participation.

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