Specific cellular responses to alpha-tocopherol.

Azzi, A; Breyer, I; Feher, M; Pastori, M; Ricciarelli, R; Spycher, S; Staffieri, M; Stocker, Achim; Zimmer, S; Zingg, J M (2000). Specific cellular responses to alpha-tocopherol. Journal of nutrition, 130(7), pp. 1649-1652. American Society for Nutrition 10.1093/jn/130.7.1649

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In the last 10 years precise cellular functions of alpha-tocopherol, some of which are independent of its antioxidant/radical-scavenging ability, have been revealed. Absorption of alpha-tocopherol from the gut is a selective process. Other tocopherols are not absorbed or are absorbed to a lesser extent. At the post-translational level, alpha-tocopherol inhibits protein kinase C and 5-lipoxygenase and activates protein phosphatase 2A and diacylglycerol kinase. Some genes [platelet glycoprotein IV/thrombospondin receptor/class B scavenger receptor (CD36), alpha-tocopherol transfer protein (alpha-TTP), alpha-tropomyosin, connective tissue growth factor and collagenase] are affected by alpha-tocopherol at the transcriptional level. alpha-Tocopherol also inhibits cell proliferation, platelet aggregation, monocyte adhesion and the oxygen burst in neutrophils. Other antioxidants, such as beta-tocopherol and probucol, do not mimic these effects, suggesting a nonantioxidant, alpha-tocopherol-specific molecular mechanism.

Item Type:	Journal Article (Review Article)
Division/Institute:	08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)
UniBE Contributor:	Stocker, Achim
Subjects:	500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry
ISSN:	0022-3166
Publisher:	American Society for Nutrition
Language:	English
Submitter:	Anja Ebeling
Date Deposited:	11 Mar 2020 15:40
Last Modified:	05 Dec 2022 15:37
Publisher DOI:	10.1093/jn/130.7.1649
PubMed ID:	10867030
URI:	https://boris.unibe.ch/id/eprint/141796