Immune complexes containing serum B-cell activating factor and immunoglobulin G correlate with disease activity in systemic lupus erythematosus.

Friebus-Kardash, Justa; Branco, Leonore; Ribi, Camillo; Chizzolini, Carlo; Huynh-Do, Uyen; Dubler, Denise; Roux-Lombard, Pascale; Dolff, Sebastian; Kribben, Andreas; Eisenberger, Ute; Trendelenburg, Marten (2018). Immune complexes containing serum B-cell activating factor and immunoglobulin G correlate with disease activity in systemic lupus erythematosus. Nephrology, dialysis, transplantation, 33(1), pp. 54-64. Oxford University Press 10.1093/ndt/gfx220

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Methods

Levels of serum BAFF, IgG anti-BAFF and BAFF-IgG complexes were quantified by enzyme-linked immunosorbent assay. IgG anti-BAFF and BAFF-IgG complexes were further characterized using serum fractions obtained by fast protein liquid chromatography. To study the association of serum BAFF, IgG anti-BAFF and BAFF-IgG complex levels with SLE manifestations, 373 visits from 178 patients prospectively included in the Swiss SLE Cohort Study were analysed.

Results

While IgG anti-BAFF levels were not associated with clinical manifestations of SLE, serum BAFF levels correlated with disease activity and were higher in patients with renal involvement. Interestingly, we could also demonstrate the occurrence of BAFF-IgG complexes of different sizes in the sera of SLE patients, which were not due to treatment with belimumab and differed from complexes constructed in vitro. Most strikingly, the levels of these BAFF-IgG complexes were found to strongly correlate with overall disease activity, low complement levels and a history of lupus nephritis.

Conclusion

BAFF-IgG complexes strongly correlate with disease activity in SLE patients, suggesting a pathogenic role in SLE.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
UniBE Contributor:	Huynh-Do, Uyen
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1460-2385
Publisher:	Oxford University Press
Language:	English
Submitter:	Uyen Huynh-Do
Date Deposited:	07 May 2020 09:30
Last Modified:	05 Dec 2022 15:38
Publisher DOI:	10.1093/ndt/gfx220
PubMed ID:	28992184
Uncontrolled Keywords:	BAFF-IgG complexes SLE disease anti-BAFF autoantibodies belimumab serum B-cell activating factor (BAFF)
URI:	https://boris.unibe.ch/id/eprint/143661