Schoster, Angelika; Weese, J. Scott; Gerber, Vinzenz; Graubner, Claudia Nicole (2020). Dysbiosis is not present in horses with fecal water syndrome when compared to controls in spring and autumn. Journal of veterinary internal medicine, 34(4), pp. 1614-1621. Wiley-Blackwell 10.1111/jvim.15778
|
Text
Dysbiosis is not present in horses with fecal water syndrome when compared to controls in spring and autumn.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
BACKGROUND
Fecal water syndrome (FWS) is long-standing and common in horses, particularly in central Europe. No large epidemiological data sets exist, and the cause remains elusive. Dysbiosis could play a role in pathogenesis.
OBJECTIVES
To evaluate whether dysbiosis is present in horses with FWS when compared to stable-matched control horses in spring and autumn.
ANIMALS
Fecal samples were collected from horses with FWS (n = 16; 9 mares, 7 geldings) and controls (n = 15; 8 mares, 7 geldings).
METHODS
The bacterial microbiome of samples collected in spring and autumn of 2016 was analyzed using high-throughput sequencing. Differences in relative abundance of bacterial taxa, alpha diversity, and beta diversity indices were assessed between horses with FWS and controls based on season.
RESULTS
Differences in microbial community composition based on time point and health status were not observed on any taxonomic level. Limited differences were seen on linear discriminant analysis effect size analysis. No difference in alpha diversity indices was observed including richness, diversity based on health status, or time point. No effect of health status on microbial community membership structure was observed.
CONCLUSIONS AND CLINICAL IMPORTANCE
Limited differences were found in the bacterial microbiota of horses with and without FWS, regardless of season. Further research is needed to elucidate the role of microbiota in the development of FWS.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > ISME Equine Clinic Bern > ISME Equine Clinic, Internal medicine 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) |
UniBE Contributor: |
Gerber, Vinzenz, Graubner, Claudia |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
0891-6640 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Ursula Therese Horst |
Date Deposited: |
30 Jul 2020 09:53 |
Last Modified: |
05 Dec 2022 15:39 |
Publisher DOI: |
10.1111/jvim.15778 |
PubMed ID: |
32588473 |
Uncontrolled Keywords: |
clostridiales fecal water syndrome gastrointestinal microbiota horse metagenomic sequencing |
BORIS DOI: |
10.7892/boris.145461 |
URI: |
https://boris.unibe.ch/id/eprint/145461 |
Actions (login required)
 |
Edit item |