Haute, Gabriela Viegas; Luft, Carolina; Antunes, Géssica Luana; Silveira, Josiane Silva; de Souza Basso, Bruno; da Costa, Mariana Severo; Levorse, Vitor Giancarlo Schneider; Kaiber, Daniela Benvenutti; Donadio, Márcio Vinícius Fagundes; Gracia-Sancho, Jordi; de Oliveira, Jarbas Rodrigues (2020). Anti-inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury. Journal of cellular physiology, 235(9), pp. 6073-6084. Wiley 10.1002/jcp.29536
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Acute lung injury (ALI) is an inflammatory process, and has high incidence and mortality. ALI and the acute respiratory distress syndrome are two common complications worldwide that result in acute lung failure, sepsis, and death. Pro-inflammatory substances, such as cytokines and chemokines, are responsible for activating the body's defense mechanisms and usually mediate inflammatory processes. Therefore, the research of substances that decrease the uncontrolled response of organism is seen as potential for patients with ALI. Octyl gallate (OG) is a phenolic compound with therapeutic actions namely antimicrobial, antiviral, and antifungal. In this study, we evaluated its action on lipopolysaccharide (LPS)-activated alveolar macrophages RAW 264.7 cells and ALI in male mice. Our results demonstrated protective effects of OG in alveolar macrophages activated with LPS and mice with ALI. The OG treatment significantly decreased the inflammatory markers in both studies in vitro and in vivo. The data suggested that OG can act as an anti-inflammatory agent for ALI.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine |
UniBE Contributor: |
Gracia Sancho, Jorge Sergio |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0021-9541 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Thi Thao Anh Pham |
Date Deposited: |
18 Dec 2020 09:33 |
Last Modified: |
05 Dec 2022 15:42 |
Publisher DOI: |
10.1002/jcp.29536 |
PubMed ID: |
31970778 |
Uncontrolled Keywords: |
acute lung injury inflammation macrophages octyl gallate |
BORIS DOI: |
10.7892/boris.148517 |
URI: |
https://boris.unibe.ch/id/eprint/148517 |
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