Seven-year-efficacy of proximal caries infiltration - Randomized clinical trial.

Paris, S; Bitter, K; Krois, J; Meyer-Lueckel, Hendrik (2020). Seven-year-efficacy of proximal caries infiltration - Randomized clinical trial. Journal of dentistry, 93(103277), p. 103277. Elsevier Science 10.1016/j.jdent.2020.103277

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OBJECTIVES

We report efficacy of resin infiltration to arrest progression of caries lesions as compared with non-invasive measures and oral hygiene education alone after a mean observation time of seven years.

MATERIALS AND METHODS

This randomized split-mouth placebo-controlled clinical trial included 22 young adults having 29 pairs of interproximal non-cavitated caries lesions with radiographic extensions into inner half of enamel (E2) or outer third of dentin (D1). Lesion pairs were randomly allocated to two treatment groups: infiltration (Icon, pre-product; DMG) or mock (control) treatment. All subjects received risk-related instructions for diet, flossing and fluoridation. The primary outcome was radiographic (digital subtraction radiography) lesion progression after seven years. Secondly, Kaplan-Meier-analyses were applied to analyze time-to-failure additionally including patients followed up for less than 54 months as well.

RESULTS

Two lesion pairs were excluded due to invasive treatment decision by another dentist, five lesion pairs were lost to follow-up prior to 54 months but included in the survival analysis. No unwanted effects could be observed. For the primary outcome in 17 patients followed up in mean for 84 months 2/22 infiltrated lesions (9 %) compared with 10/22 control lesions (45 %) progressed (p = 0.018). The relative risk reduction for test in relation to control was 80 % (CI 95 % = 19-95 %). For the survival analysis within a mean (SD) observation time of 73 (25) months mean failure rates of 1.3 % and 7.8 % could be observed for test and controls, respectively. Hazard risk (95 % CI) for caries progression was 6.6 (2-22) for the control compared with the test lesions (p = 0.002).

CONCLUSIONS

We conclude that resin infiltration of proximal caries lesions extending radiographically around the enamel dentin junction is efficacious to reduce lesion progression after a mean observation time of seven years.

CLINICAL SIGNIFICANCE

This randomized clinical trial proves that caries infiltration is highly efficacious compared with non-invasive measures and oral hygiene education alone after a considerably longer observation time of 7 years than studied so far before.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry

UniBE Contributor:

Meyer-Lückel, Hendrik

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0300-5712

Publisher:

Elsevier Science

Language:

English

Submitter:

Daniela Zesiger

Date Deposited:

23 Dec 2020 11:24

Last Modified:

05 Dec 2022 15:42

Publisher DOI:

10.1016/j.jdent.2020.103277

PubMed ID:

31931026

Uncontrolled Keywords:

Caries infiltration Caries lesion Digital subtraction Infiltrant Microinvasive RCT Resin

BORIS DOI:

10.48350/148747

URI:

https://boris.unibe.ch/id/eprint/148747

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