Surgical Management of Multiple Myeloma With Symptomatic Involvement of the Spine.

Milavec, Helena; Ravikumar, Nivetha; Syn, Nicholas L; Yentia Soekojo, Cinnie; Chng, Wee Joo; Kumar, Naresh (2020). Surgical Management of Multiple Myeloma With Symptomatic Involvement of the Spine. International journal of spine surgery, 14(5), pp. 785-794. International Society for the Advancement of Spine Surgery 10.14444/7112

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INTRODUCTION

Multiple myeloma (MM) is the most frequent primary malignancy of the spine. We aimed to investigate the clinical presentation, surgical indications and outcomes, complications, survival, and its influencing factors in surgically treated MM patients with symptomatic involvement of the spine (SIS).

METHODS

Retrospective analysis of prospectively collected data. Out of 350 MM patients treated at our institution over a period of 12 years (2006-2018), we identified 24 patients who were surgically treated for SIS. We collected data on demographics, clinical presentation, comorbidities, surgical indications, and outcomes and investigated the factors predisposing to postoperative complications and survival.

RESULTS

The median follow-up duration was 85 months; median overall survival (OS) was 50 months. Clinical presentation at admission included pain (88%), sensory and/or motor deficit (67%), and bowel/bladder dysfunction (25%). Symptomatic pathological fractures were seen in 33%. Predominant surgical indications were rapid neurological deterioration with or without spinal cord compression (SCC), followed by mechanical instability. The majority of our patients benefited from surgery in terms of pain reduction in the short term as well as in the long term. There were 21% patients with surgical-related complications (<3 months). Surgical site infections occurred in 17%, without any obvious factors predisposing to infective complications. Neurological deterioration during hospital stay, especially in the presence of motor deficit and/or bowel/bladder dysfunction, significantly reduced OS.

CONCLUSIONS

Sudden-onset neurological deterioration was the predominant factor leading to surgery. We achieved good short- and long-term pain reduction. Surgery is a valuable option for MM patients with SIS who present with rapid neurological deterioration with or without SCC and/or mechanical instability.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery

UniBE Contributor:

Milavec, Helena Maria

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2211-4599

Publisher:

International Society for the Advancement of Spine Surgery

Language:

English

Submitter:

Kathrin Aeschlimann

Date Deposited:

04 Dec 2020 14:31

Last Modified:

05 Dec 2022 15:42

Publisher DOI:

10.14444/7112

PubMed ID:

33097585

Uncontrolled Keywords:

complications functional outcomes infections multiple myeloma neurologic deficits overall survival pain pathological fractures spinal cord compression spine surgery

BORIS DOI:

10.7892/boris.149055

URI:

https://boris.unibe.ch/id/eprint/149055

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