Treatment-induced symptoms, depression and age as predictors of sexual problems in premenopausal women with early breast cancer receiving adjuvant endocrine therapy.

Ribi, Karin; Luo, Weixiu; Walley, Barbara A; Burstein, Harold J; Chirgwin, Jacquie; Ansari, Rafat H; Salim, Muhammed; van der Westhuizen, Andre; Abdi, Ehtesham; Francis, Prudence A; Chia, Stephen; Harvey, Vernon J; Giobbie-Hurder, Anita; Fleming, Gini F; Pagani, Olivia; Di Leo, Angelo; Colleoni, Marco; Gelber, Richard D; Goldhirsch, Aron; Coates, Alan S; ... (2020). Treatment-induced symptoms, depression and age as predictors of sexual problems in premenopausal women with early breast cancer receiving adjuvant endocrine therapy. Breast cancer research and treatment, 181(2), pp. 347-359. Springer 10.1007/s10549-020-05622-5

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PURPOSE

Sexual dysfunction is an important concern of premenopausal women with early breast cancer. We investigated predictors of sexual problems in two randomized controlled trials.

METHODS

A subset of patients enrolled in TEXT and SOFT completed global and symptom-specific quality-of-life indicators, CES-Depression and MOS-Sexual Problems measures at baseline, six, 12 and 24 months. Mixed models tested the association of changes in treatment-induced symptoms (baseline to 6 months), depression at 6 months, and age at randomization with changes in sexual problems over 2 years.

RESULTS

Sexual problems increased by 6 months and persisted at this level. Overall, patients with more severe worsening of vaginal dryness, sleep disturbances and bone or joint pain at 6 months reported a greater increase in sexual problems at all time-points. Depression scores were significantly associated with sexual problems in the short-term. All other symptoms had a smaller impact on sexual problems. Age was not associated with sexual problems at any time-point.

CONCLUSION

Among several key symptoms, vaginal dryness, sleep disturbance, and bone and joint pain significantly predicted sexual problems during the first 2 years. Early identification of these symptoms may contribute to timely and tailored interventions.

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